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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of protein ubiquitination
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Accession:GO:0031397 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.
Synonyms:exact_synonym: down regulation of protein ubiquitination;   downregulation of protein ubiquitination
 narrow_synonym: inhibition of protein ubiquitination

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negative regulation of protein ubiquitination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 involved_in ISO (PMID:18292230) ARUK-UCL PMID:18292230 NCBI chr24:82,704,087...82,730,711
Ensembl chr24:82,704,068...82,727,698 		JBrowse link
G ARRB1 arrestin beta 1 involved_in ISO (PMID:16378096) UniProt PMID:16378096 NCBI chr 1:66,489,358...66,580,167
Ensembl chr 1:66,490,102...66,580,154 		JBrowse link
G ARRB2 arrestin beta 2 involved_in ISO Trpv4
(PMID:16378096)		 RGD
UniProt		 PMID:16378096 PMID:20650893 RGD:5509917 NCBI chr16:4,191,040...4,202,382
Ensembl chr16:4,191,172...4,202,385 		JBrowse link
G ATG5 autophagy related 5 acts_upstream_of_or_within ISO (PMID:17450150) MGI PMID:17450150 NCBI chr13:67,482,538...67,619,201
Ensembl chr13:67,482,595...67,617,902 		JBrowse link
G BAG2 BAG cochaperone 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:14,420,196...14,432,910
Ensembl chr17:14,420,947...14,433,354 		JBrowse link
G BAG5 BAG cochaperone 5 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr24:81,496,664...81,502,969 JBrowse link
G BEX1 brain expressed X-linked 1 involved_in ISO (MGI:6790336|PMID:34562363) UniProt PMID:34562363 MGI:6790336 NCBI chr  X:90,984,435...90,986,054 JBrowse link
G BEX3 brain expressed X-linked 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:91,280,974...91,282,870
Ensembl chr  X:91,281,270...91,282,743 		JBrowse link
G BEX4 brain expressed X-linked 4 involved_in ISO (MGI:6790336|PMID:34562363) UniProt PMID:34562363 MGI:6790336 NCBI chr  X:91,119,345...91,121,417
Ensembl chr  X:91,119,396...91,120,893 		JBrowse link
G CAMLG calcium modulating ligand involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:37,527,411...37,540,405
Ensembl chr23:37,527,875...37,541,259 		JBrowse link
G CAV1 caveolin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:85,222,724...85,258,562
Ensembl chr21:85,222,879...85,258,627 		JBrowse link
G CDK5 cyclin dependent kinase 5 acts_upstream_of_or_within ISO (PMID:17591690) MGI PMID:17591690 NCBI chr21:119,235,687...119,240,163 JBrowse link
G CHP1 calcineurin like EF-hand protein 1 involved_in ISO PMID:21543739 UniProt PMID:21543739 RGD:8554239 NCBI chr26:41,734,698...41,785,273
Ensembl chr26:41,733,063...41,785,586 		JBrowse link
G CRY1 cryptochrome circadian regulator 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:102,200,822...102,306,165
Ensembl chr11:102,204,224...102,306,182 		JBrowse link
G DNAJA1 DnaJ heat shock protein family (Hsp40) member A1 involved_in ISO (PMID:12150907) ParkinsonsUK-UCL PMID:12150907 NCBI chr12:47,220,976...47,235,684 JBrowse link
G DNAJA1 DnaJ heat shock protein family (Hsp40) member A1 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr12:47,224,138...47,235,167 JBrowse link
G FYN FYN proto-oncogene, Src family tyrosine kinase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:24627473) Ensembl
MGI		 PMID:24627473 GO_REF:0000107 NCBI chr13:61,988,265...62,218,756
Ensembl chr13:62,159,874...62,219,672 		JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit acts_upstream_of_or_within ISO (PMID:17189825) MGI PMID:17189825 NCBI chr17:19,012,994...19,060,617
Ensembl chr17:19,013,026...19,060,659 		JBrowse link
G GNL3L G protein nucleolar 3 like involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:50,650,512...50,684,835
Ensembl chr  X:50,666,794...50,684,649 		JBrowse link
G GTPBP4 GTP binding protein 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:953,062...981,213
Ensembl chr 9:952,663...981,353 		JBrowse link
G HDAC8 histone deacetylase 8 involved_in ISO (PMID:16809764) BHF-UCL PMID:16809764 NCBI chr  X:62,154,374...62,393,149
Ensembl chr  X:62,154,365...62,393,196 		JBrowse link
G ISG15 ISG15 ubiquitin like modifier involved_in ISO (PMID:18305167) UniProt PMID:18305167 NCBI chr20:130,419,909...130,421,409
Ensembl chr20:130,419,782...130,421,380 		JBrowse link
G IVNS1ABP influenza virus NS1A binding protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:44,083,696...44,104,760
Ensembl chr25:44,083,762...44,104,947 		JBrowse link
G KLHL40 kelch like family member 40 acts_upstream_of_or_within ISO (PMID:24960163) MGI PMID:24960163 NCBI chr22:4,141,759...4,149,158
Ensembl chr22:4,142,192...4,148,710 		JBrowse link
G LOC103221743 heat shock 70 kDa protein 1A involved_in ISO (PMID:12150907) ParkinsonsUK-UCL PMID:12150907 NCBI chr17:40,191,695...40,194,459
Ensembl chr17:40,203,936...40,205,858 		JBrowse link
G LOC103221745 heat shock 70 kDa protein 1A involved_in ISO (PMID:12150907) ParkinsonsUK-UCL PMID:12150907 NCBI chr17:40,203,647...40,206,028
Ensembl chr17:40,203,936...40,205,858 		JBrowse link
G LOC103232401 protein BEX2 involved_in ISO (MGI:6790336|PMID:34562363) UniProt PMID:34562363 MGI:6790336 NCBI chr  X:91,212,951...91,214,607
Ensembl chr  X:91,213,194...91,213,580 		JBrowse link
G LOC103237529 adhesion G protein-coupled receptor B1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:136,704,318...136,784,581
Ensembl chr 8:136,704,341...136,783,991 		JBrowse link
G MINAR1 membrane integral NOTCH2 associated receptor 1 involved_in ISO PMID:30080879
(PMID:30080879)		 UniProt PMID:30080879 RGD:13825189 NCBI chr26:3,916,183...3,958,664
Ensembl chr26:3,920,064...3,932,619 		JBrowse link
G MTOR mechanistic target of rapamycin kinase ISO RGD PMID:21357504 RGD:10041003 NCBI chr20:120,522,667...120,678,988
Ensembl chr20:120,525,737...120,679,020 		JBrowse link
G N4BP1 NEDD4 binding protein 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:34,351,845...34,423,152
Ensembl chr 5:34,347,979...34,422,887 		JBrowse link
G NXN nucleoredoxin involved_in ISO (MGI:4868553|PMID:20970343) UniProt PMID:20970343 MGI:4868553 NCBI chr16:543,375...717,671 JBrowse link
G NXN nucleoredoxin involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 Ensembl chr16:543,561...565,576 JBrowse link
G OGT O-linked N-acetylglucosamine (GlcNAc) transferase involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:61,351,047...61,393,541
Ensembl chr  X:61,351,054...61,394,305 		JBrowse link
G PABPN1L PABPN1 like, cytoplasmic acts_upstream_of_or_within ISO (PMID:32558204) MGI PMID:32558204 NCBI chr 5:74,251,084...74,256,543
Ensembl chr 5:74,252,703...74,255,857 		JBrowse link
G PARK7 Parkinsonism associated deglycase involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:123,776,084...123,808,031
Ensembl chr20:123,776,297...123,798,434 		JBrowse link
G PELI3 pellino E3 ubiquitin protein ligase family member 3 acts_upstream_of_or_within ISO (PMID:23042151) MGI PMID:23042151 NCBI chr 1:7,800,430...7,811,226
Ensembl chr 1:7,799,182...7,811,208 		JBrowse link
G PER2 period circadian regulator 2 involved_in ISO (MGI:5572897|PMID:11889036) UniProt PMID:11889036 MGI:5572897 NCBI chr10:124,270,917...124,316,031
Ensembl chr10:124,269,543...124,315,904 		JBrowse link
G PINX1 PIN2 (TERF1) interacting telomerase inhibitor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:8,259,537...8,336,586
Ensembl chr 8:8,259,692...8,336,603 		JBrowse link
G PRKCE protein kinase C epsilon involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:61,022,903...61,570,390
Ensembl chr14:61,026,017...61,242,343 		JBrowse link
G PRKCG protein kinase C gamma involved_in ISO (MGI:5467682|PMID:23185022)
(PMID:15808853)		 UniProt
HGNC-UCL		 PMID:15808853 PMID:23185022 MGI:5467682 NCBI chr 6:46,574,560...46,600,329
Ensembl chr 6:46,575,439...46,600,364 		JBrowse link
G PRMT3 protein arginine methyltransferase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:44,486,165...44,621,002
Ensembl chr 1:44,485,880...44,620,936 		JBrowse link
G RASD2 RASD family member 2 involved_in ISO PMID:19498170 UniProt PMID:19498170 RGD:8554673 NCBI chr19:18,301,361...18,315,431
Ensembl chr19:18,302,046...18,315,492 		JBrowse link
G RPS3 ribosomal protein S3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:66,629,895...66,636,462
Ensembl chr 1:66,629,954...66,635,344 		JBrowse link
G SENP2 SUMO specific peptidase 2 involved_in ISO (PMID:22028379) CACAO PMID:22028379 NCBI chr15:3,805,916...3,853,529 JBrowse link
G SH3RF2 SH3 domain containing ring finger 2 involved_in ISO (PMID:24130170) UniProt PMID:24130170 NCBI chr23:48,512,549...48,655,652
Ensembl chr23:48,512,548...48,658,365 		JBrowse link
G SIRT7 sirtuin 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:73,785,223...73,792,773
Ensembl chr16:73,785,695...73,791,947 		JBrowse link
G SMAD7 SMAD family member 7 involved_in ISO (PMID:18593713) BHF-UCL PMID:18593713 NCBI chr18:31,993,543...32,024,088
Ensembl chr18:31,993,681...32,024,850 		JBrowse link
G SPOPL speckle type BTB/POZ protein like involved_in ISO (PMID:22632832) UniProt PMID:22632832 NCBI chr10:23,868,104...23,934,157 JBrowse link
G SPRY2 sprouty RTK signaling antagonist 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:59,357,611...59,362,705
Ensembl chr 3:59,358,394...59,359,341 		JBrowse link
G SQSTM1 sequestosome 1 involved_in ISO (MGI:4819475|PMID:20421418), (MGI:5009358|PMID:20173742)
(PMID:20452972)		 UniProt PMID:20173742 PMID:20421418 PMID:20452972 MGI:4819475 MGI:5009358 NCBI chr23:81,536,271...81,571,061
Ensembl chr23:81,558,082...81,574,830 		JBrowse link
G SVBP small vasohibin binding protein acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:20736312) MGI
TreeGrafter
Ensembl		 PMID:20736312 GO_REF:0000107 GO_REF:0000118 NCBI chr20:90,115,509...90,128,169
Ensembl chr20:90,116,353...90,127,807 		JBrowse link
G TNFAIP3 TNF alpha induced protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:35,537,103...35,553,396
Ensembl chr13:35,537,102...35,549,197 		JBrowse link
G TSPO translocator protein involved_in ISO (MGI:5689082|PMID:25470454) ParkinsonsUK-UCL PMID:25470454 MGI:5689082 NCBI chr19:25,678,602...25,690,556
Ensembl chr19:25,686,981...25,690,768 		JBrowse link
G U2AF2 U2 small nuclear RNA auxiliary factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:48,244,247...48,265,029
Ensembl chr 6:48,245,297...48,265,019 		JBrowse link
G UBXN1 UBX domain protein 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:11,228,944...11,231,549
Ensembl chr 1:11,228,135...11,231,459 		JBrowse link
G UFL1 UFM1 specific ligase 1 involved_in ISO (PMID:20164180) UniProt PMID:20164180 NCBI chr13:77,357,239...77,387,385
Ensembl chr13:77,357,141...77,387,367 		JBrowse link
G USP4 ubiquitin specific peptidase 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:10,672,920...10,735,374
Ensembl chr22:10,672,388...10,732,104 		JBrowse link
G VPS28 VPS28 subunit of ESCRT-I involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:138,636,092...138,641,011 JBrowse link
G WNK1 WNK lysine deficient protein kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:736,668...893,404
Ensembl chr11:737,590...890,762 		JBrowse link
negative regulation of protein autoubiquitination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MARCHF7 membrane associated ring-CH-type finger 7 involved_in ISO (PMID:29295817) UniProt PMID:29295817 NCBI chr10:45,121,817...45,178,547
Ensembl chr10:45,121,538...45,177,271 		JBrowse link
G TAF1 TATA-box binding protein associated factor 1 involved_in ISO (PMID:17237821) ParkinsonsUK-UCL PMID:17237821 NCBI chr  X:61,167,743...61,269,000
Ensembl chr  X:61,167,589...61,268,839 		JBrowse link
negative regulation of protein K48-linked ubiquitination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPIA peptidylprolyl isomerase A involved_in ISO (PMID:30328013) UniProt PMID:30328013 NCBI chr21:13,876,099...13,883,546
Ensembl chr21:13,876,099...13,883,462 		JBrowse link
G TRIM44 tripartite motif containing 44 involved_in ISO (PMID:23460740) BHF-UCL PMID:23460740 NCBI chr 1:29,461,928...29,592,084
Ensembl chr 1:29,464,090...29,592,270 		JBrowse link
negative regulation of protein K63-linked ubiquitination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CEP63 centrosomal protein 63 involved_in ISO (PMID:35989368) UniProt PMID:35989368 NCBI chr15:55,821,117...55,892,951
Ensembl chr15:55,821,487...55,892,398 		JBrowse link
G GPS2 G protein pathway suppressor 2 involved_in ISO (MGI:5896692|PMID:28039360)
(MGI:6148392|PMID:24953653), (MGI:6148396|PMID:29499132), (MGI:6148454|PMID:22424771)		 UniProt PMID:22424771 PMID:24953653 PMID:28039360 PMID:29499132 MGI:5896692 MGI:6148392 MGI:6148396 MGI:6148454 NCBI chr16:6,690,831...6,694,245
Ensembl chr16:6,686,667...6,693,804 		JBrowse link
G PARP10 poly(ADP-ribose) polymerase family member 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:138,187,635...138,195,541
Ensembl chr 8:138,187,562...138,195,504 		JBrowse link
negative regulation of protein polyubiquitination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DYSF dysferlin acts_upstream_of_or_within ISO (PMID:20724702) MGI PMID:20724702 NCBI chr14:35,488,393...35,715,222
Ensembl chr14:35,488,391...35,651,395 		JBrowse link
G TTC36 tetratricopeptide repeat domain 36 acts_upstream_of_or_within ISO (PMID:31537781) MGI PMID:31537781 NCBI chr 1:109,912,976...109,917,097 JBrowse link
G TTC36 tetratricopeptide repeat domain 36 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 1:109,913,430...109,917,024 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16925
    metabolic process 10515
      primary metabolic process 9205
        protein metabolic process 4065
          protein modification process 1982
            post-translational protein modification 894
              negative regulation of post-translational protein modification 87
                negative regulation of protein modification by small protein conjugation or removal 83
                  negative regulation of protein ubiquitination 70
                    negative regulation of protein autoubiquitination 2
                    negative regulation of protein monoubiquitination 0
                    negative regulation of protein polyubiquitination + 8
                    negative regulation of ubiquitin-protein transferase activity + 0
Path 2
Term Annotations click to browse term
  biological_process 16925
    metabolic process 10515
      organic substance metabolic process 10067
        macromolecule metabolic process 8484
          protein metabolic process 4065
            protein modification process 1982
              post-translational protein modification 894
                protein modification by small protein conjugation or removal 856
                  protein modification by small protein conjugation 770
                    protein ubiquitination 693
                      regulation of protein ubiquitination 181
                        negative regulation of protein ubiquitination 70
                          negative regulation of protein autoubiquitination 2
                          negative regulation of protein monoubiquitination 0
                          negative regulation of protein polyubiquitination + 8
                          negative regulation of ubiquitin-protein transferase activity + 0
paths to the root